解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The uterotropic response of the uterus to 17β-estradiol (E2) is genetically controlled, with marked variation observed depending on the mouse strain studied. Previous genetic studies from our laboratory using inbred mice that are high (C57BL6/J; B6) or low (C3H/HeJ; C3H) responders to E2 led to the identification of q...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1910
更新日期:2014-08-01 00:00:00
abstract::Fasting in rodents is characterized by decreases in serum T4 and T3 levels but no compensatory increase in serum TSH level. The types 1 and 2 deiodinases (D1 and D2) are postulated to play key roles in mediating these changes. However, serum T4 and T3 levels in fasted 5'-deiodinase-deficient mice decreased by at least...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1884
更新日期:2014-08-01 00:00:00
abstract::PTH upregulates the expression of the receptor activator of nuclear factor κB ligand (Rankl) in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell responsible for RANKL-mediated stimulation of bone resorption remains undefined. We report that constitutive activation of PTH ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1046
更新日期:2014-08-01 00:00:00
abstract::The consumption of refined sugars continues to pose a significant health risk. However, nearly nothing is known about the effects of sugar intake by healthy women on the oocyte or embryo. Using rhesus monkeys, we show that low-dose sucrose intake over a 6-month period has an impact on the oocyte with subsequent effect...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1104
更新日期:2014-07-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed at a high level in the fetal pituitary and decreases profoundly between embryonic day 19 and postnatal day 1 (PN1), with a further decrease from PN1 to PN4. In this series of experiments, we investigated the hypothesis that dopamine 2 receptor (Dr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2147
更新日期:2014-07-01 00:00:00
abstract::Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the proinflammatory cytokine IL-6, but whether it is present in the fetal circulation and how it acts on the developing fetus are unclear. We first observed that postnatal day 0 o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1968
更新日期:2014-07-01 00:00:00
abstract::Thyroid dysfunction during human pregnancy is closely related to serious pregnancy outcome. However, the regulation and function of thyroid hormones during early pregnancy are largely unknown. We found that type II deiodinase, an enzyme converting T4 to activated T3, is highly expressed in the mouse uterus on days 3 a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2014-1015
更新日期:2014-07-01 00:00:00
abstract::Mutations in the PCSK1 gene encoding prohormone convertase 1/3 (PC1/3) are strongly associated with obesity in humans. The PC1/3(N222D) mutant mouse thus far represents the only mouse model that mimics the PC1/3 obesity phenotype in humans. The present investigation addresses the cell biology of the N222D mutation. Me...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1985
更新日期:2014-07-01 00:00:00
abstract::Hypoglycemia associated with diabetes management is a potential risk for cardiovascular diseases. However, the effect of hypoglycemic episodes including a surge of sympathetic activity on the progression of neointima formation after vascular injury remains largely unknown. In this study, insulin was injected intraperi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1628
更新日期:2014-06-01 00:00:00
abstract::GH is an important regulator of body growth and composition as well as numerous other metabolic processes. In particular, liver plays a key role in the GH/IGF-I axis, because the majority of circulating "endocrine" IGF-I results from GH-stimulated liver IGF-I production. To develop a better understanding of the role o...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2086
更新日期:2014-05-01 00:00:00
abstract::Kisspeptin regulates reproductive events, including puberty and ovulation, primarily via GnRH neurons. Prolonged treatment of prepubertal striped bass females with kisspeptin (Kiss) 1 or Kiss2 peptides failed to enhance puberty but suggested a gnrh-independent pituitary control pathway. Kiss2 inhibited, but Kiss1 stim...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1894
更新日期:2014-05-01 00:00:00
abstract::To address the neural mediation of the eating-inhibitory effect of circulating glucagon-like peptide-1 (GLP-1), we investigated the effects of 1) intra-fourth ventricular infusion of the GLP-1 receptor antagonist exendin-9 or 2) area postrema lesion on the eating-inhibitory effect of intrameal hepatic portal vein (HPV...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1447
更新日期:2014-05-01 00:00:00
abstract::The inhibitory effect of stress on reproductive function is potentially mediated by high concentrations of circulating glucocorticoids (GCs) acting via the GC receptor (GR). Gonadotropin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotropin secretion. GnIH may mediate stress-induced repro...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2076
更新日期:2014-05-01 00:00:00
abstract::Liver receptor homolog-1 (LRH-1) is an orphan nuclear receptor that belongs to the NR5A subgroup of nuclear receptors. LRH-1 induces key genes to regulate metabolic process, ovarian function, cancer cell proliferation, and steroidogenesis. In the breast, LRH-1 modulates and synergizes with endogenous estrogen signalin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1948
更新日期:2014-05-01 00:00:00
abstract::The melanocortin-3 receptor (MC3R) and MC4R are known to play critical roles in energy homeostasis. However, the physiological functions of the MC3R remain poorly understood. Earlier reports indicated that the ventral tegmental area (VTA) is one of the highest sites of MC3R expression, and we sought to determine the f...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2049
更新日期:2014-05-01 00:00:00
abstract::We have previously demonstrated that, in prostate cancer cells, androgens up-regulate IGF-I receptor (IGF-IR) by inducing cAMP-response element-binding protein (CREB) activation and CREB-dependent IGF-IR gene transcription through androgen receptor (AR)-dependent membrane-initiated effects. This IGF-IR up-regulation i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1925
更新日期:2014-04-01 00:00:00
abstract::A major issue of in the treatment of diabetes is the risk of hypoglycemia. Hypoglycemia is detected both centrally and peripherally in the porto-hepatic area. The portal locus for hypoglycemic detection was originally described using the "local irrigation of the liver" approach in a canine model. Further work using po...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1794
更新日期:2014-04-01 00:00:00
abstract::The microenvironment of placental mesenchymal stem cells (PMSCs) is dynamic throughout gestation and determines changes in cell fate. In vivo, PMSCs initially develop in low-oxygen tension and low IGF-I concentrations, and both increase gradually with gestation. The impact of varying concentrations of IGF-I and changi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1842
更新日期:2014-04-01 00:00:00
abstract::Bisphosphonates are effective for preventing and treating skeletal disorders associated with hyperresorption. Their safety and efficacy has been studied in adults where the growth plate is fused and there is no longitudinal bone growth and little appositional growth. Although bisphosphonate use in the pediatric popula...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1993
更新日期:2014-04-01 00:00:00
abstract::Acromegaly is associated with an increased incidence of cardiovascular disease. Transgenic mice expressing bovine GH (bGH) gene have previously been used to examine the effects of chronic GH stimulation on cardiovascular function. Results concerning systolic blood pressure (SBP) in bGH mice are conflicting. We hypothe...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1899
更新日期:2014-03-01 00:00:00
abstract::During in vitro maturation of porcine cumulus cell-oocyte complexes and in vitro luteinization of porcine granulosa cells, FSH induces the expression of the protease TNFα-converting enzyme/A disintegrin and metalloproteinase domain 17 (TACE/ADAM17) and the epidermal growth factor (EGF)-like factors, which activate the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1655
更新日期:2014-03-01 00:00:00
abstract::Adipose tissue inflammation is associated with the development of insulin resistance. In obese adipose tissue, lipopolysaccharides (LPSs) and saturated fatty acids trigger inflammatory factors that mediate a paracrine loop between adipocytes and macrophages. However, the inflammatory signaling proteins underlying this...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1815
更新日期:2014-03-01 00:00:00
abstract::Prostaglandin (PG) E2 (PGE(2)) plays a central role in the regulation of smooth muscle contractions. Classically, PGE(2) stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1761
更新日期:2014-02-01 00:00:00
abstract::The paucity of clinical and preclinical studies investigating sex differences in sleep has resulted in mixed findings as to the exact nature of these differences. Although gonadal steroids are known to modulate sleep in females, less is known about males. Moreover, little evidence exists concerning the origin of these...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1624
更新日期:2014-01-01 00:00:00
abstract::The monocarboxylate transporter Mct10 (Slc16a10; T-type amino acid transporter) facilitates the cellular transport of thyroid hormone (TH) and shows an overlapping expression with the well-established TH transporter Mct8. Because Mct8 deficiency is associated with distinct tissue-specific alterations in TH transport a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1800
更新日期:2014-01-01 00:00:00
abstract::In mammals, lactation is associated with a period of infertility characterized by the loss of pulsatile secretion of GnRH and cessation of ovulatory cycles. Despite the importance of lactational infertility in determining overall fecundity of a species, the mechanisms by which the suckling stimulus suppresses GnRH sec...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1621
更新日期:2014-01-01 00:00:00
abstract::Enhanced epinephrine secretion from adrenal chromaffin cells (ACCs) is an important homeostatic response to severe systemic inflammation during sepsis. Evidence suggests that increased activation of ACCs by preganglionic sympathetic neurons and direct alterations in ACC function contribute to this response. However, t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1623
更新日期:2014-01-01 00:00:00
abstract::LH receptor (LHR) expression in the ovary is regulated by the RNA binding protein, (LHR mRNA binding protein [LRBP]), which has been identified as being mevalonate kinase. This study examined the role of microRNA miR-122 in LRBP-mediated LHR mRNA expression. Real-time PCR analysis of ovaries from pregnant mare serum g...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1619
更新日期:2013-12-01 00:00:00
abstract::Hyperaldosteronism is linked to the development and progression of several different cardiovascular diseases. Angiotensin (Ang) II increases aldosterone secretion and adrenal blood flow. Ang II peptide fragments are produced by various peptidases, and these Angs have diverse and vital physiologic roles. Due to the unc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1160
更新日期:2013-12-01 00:00:00
abstract::Transcription activator-like effector nucleases (TALENs) are a powerful approach for targeted genome editing and have been proved to be effective in several organisms. In this study, we reported that TALENs can induce somatic mutations in Nile tilapia, an important species for worldwide aquaculture, with reliably high...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1451
更新日期:2013-12-01 00:00:00
abstract::Women with polycystic ovary syndrome (PCOS) and hyperandrogenism have altered hormone levels and suffer from ovarian dysfunction leading to subfertility. We have attempted to generate a model of hyperandrogenism by feeding mice chow supplemented with dehydroepiandrosterone (DHEA), an androgen precursor that is often e...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2140
更新日期:2013-12-01 00:00:00
abstract::Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin driving GnRH release and neurokinin B (NKB) and dynorphin acting as start and stop signals, respectively. In this study, we tested this hypothesis...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1331
更新日期:2013-11-01 00:00:00
abstract::Abnormally high GH/IGF-I levels, most often caused by adenomas arising from pituitary somatotrophs, generate deleterious effects. We recently described a targeted secretion inhibitor (SXN101742) comprising a GHRH domain and the endopeptidase domain of botulinum toxin serotype D (GHRH-light chain endopeptidase type D d...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1427
更新日期:2013-11-01 00:00:00
abstract::Aggression enables individuals to obtain and retain limited resources. Studies of the neuroendocrine regulation of aggression have focused on territorial and reproductive contexts. By contrast, little is understood concerning the neuroendocrine regulation of aggression over other resources, such as food. Here, we deve...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1171
更新日期:2013-11-01 00:00:00
abstract::The expression of short-chain fatty acid receptors GPR41/FFAR3 and GPR43/ free fatty acid receptor 2 (FFAR2) was studied in the gastrointestinal tract of transgenic monomeric red fluorescent protein (mRFP) reporter mice. In the stomach free fatty acid receptor 3 (FFAR3)-mRFP was expressed in a subpopulation of ghrelin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1142
更新日期:2013-10-01 00:00:00
abstract::The conceptus and endometrium secrete large amounts of prostaglandin E₂ (PGE₂) into the porcine uterine lumen during the periimplantation period. We hypothesized that PGE₂ acts on conceptus/trophoblast cells through auto- and paracrine mechanisms. Real-time RT-PCR analysis revealed that PGE₂ receptor (PTGER)2 mRNA was...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2271
更新日期:2013-10-01 00:00:00
abstract::Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2004
更新日期:2013-10-01 00:00:00
abstract::Brown adipose tissue (BAT) is a major site of nonshivering thermogenesis in mammals. Rodent studies indicated that BAT thermogenic activity may protect against obesity. Recent findings using novel radiodiagnosis procedures revealed unanticipated high activity of BAT in adult humans. Moreover, complex processes of cell...
journal_title:Endocrinology
pub_type: 杂志文章,评审
doi:10.1210/en.2013-1403
更新日期:2013-09-01 00:00:00
abstract::Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an antiadrenergic/nitric oxide-cGMP mediated mechanism. Whether these phenomena are related is unknown. We here investigated whether and to what extent ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2210
更新日期:2013-09-01 00:00:00
abstract::Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In vitro studies investigated the capacity of differentiated C2 murine muscle cell...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2245
更新日期:2013-09-01 00:00:00